姓名:赵红业
职务:无
职称:教授
学科:基础兽医学
导师类别:博导
电子邮箱:hyzhao2000@126.com
教育经历
开始年月至结束年月,机构,院系,学历。
1992/9-1996/7 云南农业大学 农学学士
1996/9-1999/7 华南农业大学 农学硕士
2002/4-2004/3 日本鹿儿岛大学农学研究科 农学硕士
2004/3-2008/6 日本鹿儿岛大学医齿学综合研究科 医学博士
工作经历
开始年月至结束年月,机构,部门,职称。
2008/11-2009/3 日本德岛文理大学健康科学研究所 客员研究员
2009/10-2010/8 云南农业大学生物多样性国家研究中心 讲师
2010/8-2021/12 云南农业大学生物多样性国家研究中心 教授
2022/1-至今 皇冠买足球的官网 教授
所授课程
1. 实验动物学
2. 动物福利
3. 动物福利与伦理
4. 科研诚信与学术道德教育
5. 繁殖生物工程学
6. 细胞分子生物学
研究领域与方向
1. 人类重大疾病基因编辑小型猪模型创制
2. 免疫人源化基因编辑猪模型开发
3. 抗癌药老药新用机制研究
科研与教学
代表性科研项目
1. 基因编辑疾病模型猪创制项目,江西农业大学,2022/01-2023/12,200万,在研,主持;
2. 基因编辑克隆猪合作协议,杭州启函生物科技有限公司合作项目,2021/01-,131.8万,在研,主持;
3. 异种器官移植多基因修饰克隆猪的构建,杭州启函生物公司横向项目,2018/3-2019/3,200万,在研,主持;
4. 自噬在紫杉醇抑制乳腺癌中的作用及其机制研究,国家自然科学基金面上项目,81872452,2019/1-2022/12,57万,在研,主持;
代表性参与项目:
5.猪-非人灵长类异种器官移植关键技术的创新与应用,云南省科技厅,2021-2023,1250万,在研,参与;
6.人类重大疾病小型猪模型的构建及平台建设,云南省科技厅,2021-2024,6000万,在研,参与;
7. 云南省科技创新人才计划“云南农业大学动物基因编辑和体细胞克隆技术省创新团队”,2017/8-2020/8,100万,在研,参与;
教学项目
无
学术荣誉与奖励
赵红业(2/9),云南省技术发明一等奖,云南省人民政府,科学技术奖,一等奖,2021年,(魏红江,赵红业,卿玉波,王文,陈翔,成文敏,李鸿辉,贾宝瑜,王配)。
代表性成果
代表性文章
[1] Kaixiang Xu#, Honghao Yu#, Shuhan Chen#, Yaxuan Zhang#, Jianxiong Guo, Chang Yang, Deling Jiao, Tien Dat Nguyen, Heng Zhao, Jiaoxiang Wang, Taiyun Wei, Honghui Li, Baoyu Jia, Muhammad Ameen Jamal, Hong-Ye Zhao*, Xingxu Huang*, Hong-Jiang Wei*. Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation. Frontiers in Veterinary Science. 2022. 9:848833.
[2] Kaixiang Xu#, Wanyun Zhu#, Anyong Xu#, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei*, Hong-Ye Zhao* . Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells. Molecular Medicine Reports. 2021, 1. 25(2):72. doi: 10.3892/mmr.2022.12588.
[3] Honghui Li#, Wenmin Cheng#, Bowei Chen#, Shaoxia Pu, Ninglin Fan, Xiaolin Zhang, Deling Jiao, Dejia Shi, Jianxiong Guo, Zhuo Li, Yubo Qing, Baoyu Jia, Hong-Ye Zhao*, Hong-Jiang Wei*. Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing. Life (Basel). 2021, 11(12):1417. DOI: 10.3390/life11121417.
[4] Yubo Qing#, Muhammad Ameen Jamal#, Dejia Shi#, Sumei Zhao, Kaixiang Xu, Deling Jiao, Heng Zhao, Honghui Li, Baoyu Jia, Haizhen Wang, Hong-Ye Zhao* , Hong-Jiang Wei*. Delayed body development with reduced triglycerides levels in leptin transgenic pigs. Transgenic Research. 2021, DOI: 10.1007/s11248-021-00288-1.
[5] Luhan Yang, George Church, Hong-Ye Zhao, Lusheng Huang, Yangbin Gao, Hong-Jiang Wei, Geoffrey Yang. Porcine germline genome engineering. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(22): e2004836117. DOI: 10.1073/pnas.2004836117. (IF=11.201)
[6] Yanan Yue#, Weihong Xu#, Yinan Kan#, Hong-Ye Zhao#, Yixuan Zhou, Xiaobin Song, Jiajia Wu, Juan Xiong, Dharmendra Goswami, Meng Yang, Lydia Lamriben, Mengyuan Xu, Qi Zhang, Yu Luo, Jianxiong Guo, Shengyi Mao, Deling Jiao, Tien Dat Nguyen, Zhuo Li, Jacob V. Layer, Mailin Li, Violette Paragas, Michele E. Youd, Zhongquan Sun, Yuan Ding, Weilin Wang, Hongwei Dou, Lingling Song, Xueqiong Wang, Lei Le, Xin Fang, Haydy George, Ranjith Anand, Shi Yun Wang, William F. Westlin, Marc Güell, James Markmann, Wenning Qin, Yangbin Gao, Hong-Jiang Wei*, George M. Church*, Luhan Yang*. Extensive germline genome engineering in pigs. Nature Biomedical Engineering. 2020, 5(2):134-143 DOI: 10.1038/s41551-020-00613-9. (IF=18.952)
[7] Honghao Yu#, Weihu Long#, Xuezeng Zhang#, Kaixiang Xu, Jiangxiong Guo, Heng Zhao, Honghui Li, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao*, Xingxu Huang* and Hong-Jiang Wei*. Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer. Journal of translational medicine. 2018, 16:41. (IF=4.197)
[8] Yongfeng Shen#, Kaixiang Xu#, Zaimei Yuan, Jiangxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao*, Wei Hong-Jiang*. Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer. Journal of translational medicine. 2017, 15:224-234. (IF=4.197)
[9] Chaoxiang Lv#, Hao Qu#, Wanyun Zhu, Kaixiang Xu, Anyong Xu, Baoyu Jia, Yubo Qing, Honghui Li, Hong-Jiang Wei*, Hong-Ye Zhao*. Low-Dose Paclitaxel Inhibits Tumor Cell Growth by Regulating Glutaminolysis in Colorectal Carcinoma Cells. Frontiers in Pharmacology. 2017, 8:244. (IF=4.481)
[10] Hong-Ye Zhao, Ooyama A, Yamanoto M, Ikeda R, Haraguchi M, Tabata S, Furukawa T, Che XF, Zhang S, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M,Akiyama S. Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU. Cancer research. 2008, 68(17): 7035-7041. (IF=9.329)
[11] Hong-Ye Zhao, Ooyama, A, Yamamoto M, Ikeda R, Haraguchi M, Tabata S, Furukawa T, Che XF, Iwashita K, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M, Akiyama S. Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells. Cancer letters. 2008, 270(1):156-163. (IF=5.621)
[12] Junchen Chen , Weiqi Zeng , Weirong Pan , Cong Peng, Jianglin Zhang, Juan Su, Weihu Long, Heng Zhao, Xiaoxia Zuo, Xiaoyun Xie, Jing Wu, Ling Nie, Hong-Ye Zhao, Hong-Jiang Wei , Xiang Chen. Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs. PLoS Biol. 2018, 16(8): e2005354. (IF= 9.163)
[13] Dong Niu *, Hong-Jiang Wei *, Lin Lin*, Haydy George *, Tao Wang *, I-Hsiu Lee *, Hong-Ye Zhao, Yong Wang, Yinan Kan, Ellen Shrock, Emal Lesha, Gang Wang, Yonglun Luo, Yubo Qing, Deling, Jiao, Heng Zhao, Xiaoyang Zhou, Shouqi Wang, Hong Wei, Marc Guell, George M. Church and Luhan Yang. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science. 2017, 357:1303-1307. (IF= 41.058)
[14] Honghao Yu#, Heng Zhao#, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Xingxu Huang*, Hong-Jiang Wei*. Porcine zygote injection with Cas9/sgRNA Results in DMD-modified pig with muscle dystrophy. International journal of molecular sciences. 2016, 17: 1668. (IF=3.257)
[15] Ooyama A, Oka T, Hong-Ye Zhao, Yamamoto M, Akiyama S, Fukushima M. Anti-angiogenic effect of 5-fluorouracil-based drugs against human colon cancer xenografts. Cancer letter. 2008, 267(1): 26-36. (IF=5.621)
著作
无
代表性专利
[1] 赵红业,魏红江,申友锋,李鸿辉,赵恒,角德灵. 通过敲除P53基因获得淋巴瘤小型猪疾病模型的方法,2019年3月15日授权,中国,ZL 201510717721.9;
[2] 魏红江,李鸿辉,赵红业,卿玉波,角德灵. 一种构建过量表达Leptin基因的克隆猪的方法,2019年3月5日授权,中国,ZL 201510715885.8;
[3] 魏红江,王文,卿玉波,赵红业,角德灵. 一种利用体细胞克隆技术培育地方优良家畜品种的方法,2019年7月12日授权,中国,ZL201611224097.X;
[4] 魏红江,赵红业,赵鲁. 一种利用连续克隆技术生产孤雌生殖克隆猪的方法,2017年7月25日授权,中国,ZL 201310295393.9;
[5] 魏红江,角德灵,赵红业,王跃宁,芮绍辉,何瑞清,钟文庆,余波. 一种装配式可移动标准化饲养羊舍,2017年7月28日授权,中国,ZL 201610665810.8;
写给学生的话
简单的事重复做,你就是专家,重复的事用心做,你就是赢家。